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KMID : 1123920030170010225
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 1 p.225 ~ p.229
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Curative Effects of Typhae Pollen on the Diet-Induced Hyperlipidemia in Rats
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Shin Hyung-Seop
Kim Geu-Yeul
Kim Ho-Hyun
Seo Il-Bok
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Abstract
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In Oriental Medicine, hyperlipidemia is considered as the phlegm stagnancy(痰飮) and blood stasis(瘀血). Typhae Pollen helps remove blood stasis and hemorrhage and it also has an effect of relieving pains caused by blood stasis. The purpose of this study is to investigate the curative effects of Typhae Pollen on diet-induced hyperlipidemia in rats. Thirty-two rats were divided into normal, control and treated group. Control and treated group were fed with 1.5% cholesterol diet during 4 weeks, and fed with normal diet during next 4 weeks. Treated group was also administrated with extract of Typhae Pollen during last 4 weeks. Blood samples were collected from each of animals at 4, 6 and 8weeks, and used for the blood chemical analysis. Animals were sacrificed at 8 weeks, and chemical analysis was performed on the collected liver samples. The serum total cholesterol(47.82±2.03㎎/㎗), LDL-cholesterol(11.09±1.27㎎/㎗), HDL-cholesterol (19.64±1.23㎎/㎗), triglyceride(85.09±3.48㎎/㎗) values of treated group were significantly decreased compared with the serum total cholesterol(73.73±5.34㎎/㎗), LDL-cholesterol(22.09±3.09㎎/㎗), HDL-cholesterol(25.18±1.45㎎/㎗l), triglyceride(124.27±6.72㎎/㎗) values of control group at 8weeks. The liver total cholesterol and triglyceride values of treated group show no statistically significant differency compared with those values of control group. On the basis of these results, it is confirmed that Typhae Pollen has the curative effects on the hyperlipidemia in rats induced by hyper-cholesterol diets.
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KEYWORD
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Typhae Pollen(蒲黃), hyperlipidemia, cholesterol, triglyceride
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